Abstract
Sanjay Kumar: „Can re-entrance be observed in the temperature-force diagram of force-induced transitions?”
Department of Physics, Banaras Hindu University, Varanasi, India
A large conformational change in the reaction co-ordinate and the role of the solvent in the formation of base- pairing are combined to settle a long standing issue related to the forced induced transitions of DNA. Prediction of re-entrance i.e. a strand goes to the closed state from the open state and again to the open state with temperature has not been observed so far experimentally. An experimental protocol in the constant force ensemble is being proposed for the first time that will enable the observation of the re-entrance behavior in the force-temperature plane. Our exact results for small oligonucleotide that forms a hairpin structure provide the evidence that re-entrance can be observed at the ambient condition.